电刺激大鼠束旁核对底丘脑核与丘脑腹内侧核神经元的影响.pdfVIP

Acta Physiologica Sinica, February 25, 2007, 59 (1): 79-85 79 1 2 3 1 1,* 1 2 3 430030 110016 121001 (parafascicular nucleus, PF)(Parkinson’s disease, PD) Sprague-Dawley 6- PD PF PF (subthalamic nucleus, STN)(ventromedial nucleus, VM) (130 Hz, 0.4 mA, 5 s) PF PD PF PD STN P F VM (glutamic acid, Glu)MK-801 STN γ- (γ-amino bu- tyric acid, GABA)(picrotoxin, Pic) GABA Glu STN PFSTN Glu STN VM PF PFSTN VM PD R3 38 .2 Effects of electrical stimulation of the parafascicular nucleus on the neuronal activities of the subthalamic nucleus and the ventromedial nucleus in rats 1 2 3 1 1,* LIN Fan-Kai , XIN Yan , GAO Dong-Ming , XIONG Zhe , CHEN Jian-Guo 1Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyan 110016, China; Department of Physiology, Liaoning Medical College, Jinzhou 121001, China Abstract: The present study was designed to investigate the function and mechanism of high-frequency stimulation (HFS) of the parafascicular nucleus (PF) used as a therapeutic approach for Parkinson’s disease (PD). PD rat model was built by injecting 6-hydroxydopamine (6-OHDA) into the substartia nigra pars compacta of adult male Sprague-Dawley rats. Using the ethological methods, we examined the effect of electrical stimulation of PF on the apomorphine-induced rotational behavior in PD rats. Moreover, Electrophysiological recordings were made in rats to investigate the effects of electrical stimulation of PF on the neuronal activities of the subthalamic nucleus (STN) and the