干细胞移植治疗糖尿病肾病：可能可行和应用.docVIP

干细胞移植治疗糖尿病肾病：可能可行与应用 何晏清，杨? 萍 湖北医药学院附属太和医院，湖北省十堰市? 442000 Stem cell transplantation for diabetic nephropathy: possibility, feasibility and application He Yan-qing, Yang Ping Taihe Hospital Affiliated to Medical College of Hubei University of Medicine, Shiyan 442000, Hubei Province, China 摘要? 背景：糖尿病肾病的治疗思路主要集中在控制血糖、血压、血脂等危险因素以及抑制肾素-血管紧张素系统，但治疗效果并不理想。病情严重者可接受血液透析和肾移植，但肾源有限，费用昂贵，限制了其发展。以干细胞为基础的再生医学研究有可能为糖尿病肾病的治疗带来新的希望。目的：综合分析不同来源干细胞治疗糖尿病肾病的机制及临床研究进展。方法：应用计算机检索CNKI 和PubMed 数据库中2005 年1 月至2013 年8 月关于干细胞治疗糖尿病肾病的文章，在标题和摘要中以“胚胎干细胞；骨髓间充质干细胞；诱导性多能干细胞；糖尿病肾病”或embryonic stem cells; bone marrow mesenchymal stem cells; induced poluripotent stem cells; induced multipotent stem cells; diabetic nephropathy”为检索词进行检索。最终选择60篇文章进行综述。结果与结论：大量研究表明干细胞移植对肾脏损伤和修复具有积极的作用，诱导性多能干细胞、胚胎干细胞、骨髓间充质干细胞均具有向肾脏组织细胞分化的潜能，干细胞移植有可能为糖尿病肾病提供一种新型的治疗方案。 中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程 全文链接： 关键词?：?干细胞；?移植；?胚胎干细胞；?骨髓间充质干细胞；?诱导性多能干细胞；?糖尿病肾病； ?? Abstract： BACKGROUND:?To control blood glucose, blood pressure, blood lipids and inhibit the rennin-angiotensin system is the main idea focused on the treatment of diabetic nephropathy, but the curative effect is unsatisfactory. Hemodialysis and kidney transplantation are suitable for serious cases, however, which is restricted because of the limited source of kidneys and high cost. Regenerative medicine research based on stem cells brings a new hope for treatment of diabetic nephropathy.OBJECTIVE:?To comprehensively analyze the mechanism underlying different sources of stem cells for treatment of diabetic nephropathy and the clinical implications.METHODS:?Papers addressing stem cells for the treatment of diabetic nephropathy were retrieved by computer in CNKI database and PubMed database from January 2005 to August 2013 with the key words “embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells, diabetic nephropathy in Chinese and English. Papers published recently or in journals wit