脑卒中后星形胶质细胞反应：如何有利于轴突重塑与神经功能恢复.docVIP

脑卒中后星形胶质细胞反应：如何有利于轴突重塑和神经功能恢复 几十年来，脑卒中的治疗方法主要集中在神经保护方面，即一种治疗受损组织，并旨在减少脑梗塞体积的干预方法。各实验室方面也投入大量努力一直致力于神经保护剂的开发，并试图从不可逆的脑损伤中保护缺血神经元；然而，所有这些尝试都未能在临床试验中证明其对脑卒中的疗效。来自美国亨利?福特医院的Zhongwu Liu教授指出为了治疗脑卒中，需要重新构思、重新定义治疗目标。因此，更有前景的治疗方法是通过神经血管可塑性促进中枢神经系统的重塑，并由此促进神经恢复。脑卒中影响大脑的所有细胞成分，包括血管细胞，神经元，星形胶质细胞，少突胶质细胞，小胶质细胞和室管膜细胞等。因此，要做到这一点并扩大治疗目标范围，必须考虑有利于多种细胞类型的治疗方法，且针对星形胶质细胞的治疗尤为重要。相关研究内容发表在2014年11月第21期《中国神经再生研究（英文版）》杂志上。 Article: Reactive astrocytes promote axonal remodeling and neurological recovery after stroke by Zhongwu Liu, Hongqi Xin, Michael Chopp (Department of Neurology, Henry Ford Hospital, Detroit, MI, USA (Liu Z, Xin H, Chopp M); Department of Physics, Oakland University, Rochester, MI, USA (Chopp M)) Liu Z, Xin H, Chopp M. Reactive astrocytes promote axonal remodeling and neurological recovery after stroke. Neural Regen Res. 2014;9(21):1874-1875. 欲获更多资讯： Neural Regen Res. Role of reactive astrocytes in axonal remodeling and neurological recovery after stroke Stroke is a leading cause of death and disability in adults worldwide. For decades, the primary approach and goal of therapy for stroke has focused on neuroprotection, namely treating the injured tissue, with interventions designed to reduce the volume of cerebral infarction. Enormous effort in the laboratory has been devoted to the development of neuroprotective agents in an attempt to salvage ischemic neurons in the brain from irreversible injury; however, all these efforts have failed to demonstrate efficacy in clinical trials of stroke. Prof. Zhongwu Liu from Henry Ford Hospital, USA pointed that in order to treat stroke, we have to re-conceptualize and redefine our therapeutic targets. Acute neuroprotective treatments for stroke fight a temporal battle of salvaging cerebral tissue before the onset of death, as well as a physiological impediment of delivery of therapy to tissue which has inadequate blood flow. Thus, a more promising therapeutic approach would be to promote remodeling of the central nervous system vi