溶栓治疗对急性心肌梗死患者血浆ET-1、hs2CRP、TXA2、NO水平影响.pdfVIP

溶栓治疗对急性心肌梗死患者血浆ET-1 、hs2CRP 、TXA2 、NO 水平的影响 贺青军,罗子幸,余秀兰,王文会,罗智敏 摘要:目的 探讨溶栓治疗对急性心肌梗死 AMI 患者血浆内皮素 ET-1 、超敏C 反应蛋 白 hs2CRP 、血栓素A2 TXA2 、一氧化氮 NO 水平的影响及其临床意义。方法 病例 组32 例,采用尿激酶溶栓治疗,分别测出溶栓前后再通组和未通组ET-1 、NO、hs2CRP、TXA2 水平的动态变化。正常对照组测空腹ET-1 、NO、hs2CRP、TXA2 水平。结果 病例组ET-1 、 hs2CRP、TXA2 水平高于正常对照组 P 0. 05 ,NO 水平低于正常对照组 P 0. 05 ; 溶栓再通组的ET-1 、NO、hs2CRP、TXA2 水平显著增高,且峰值显著高于溶栓未通组的峰值 P 0. 05 ;再通组ET-1 、hs2CRP、TXA2 和NO 峰值提前,都在溶栓后3 h ,而溶栓未通组峰 值均为溶栓后5h。结论 ET-1 、hs2CRP、TXA2 和NO 相互作用,参与了AMI 的循环炎症反应 和再灌注损伤,可作为判断AMI 病情及溶栓治疗再通的可能指标。 关键词:急性心肌梗死;溶栓;内皮素-1 ;超敏C 反应蛋白;血栓素A2 ;一氧化氮 Effect of Thrombolytic Therapy on Plasma Endothelin ,hs 2CRP,TXA2 ,and NO in Acute Myocardial Infarction He Qingjun ,Luo Zixing ,Yu Xiulan , et al Foshan Hospital of Traditional Chinese Medicine ,Guangdong Foshan 528000 Abstract :Objective To study the effect of thrombolytic therapy patient s on plasma endothelin2 1 ET- 1 ,high sensitive C2reactive protein hs2CRP ,thromboxane A2 TXA2 ,nitric oxide NO levels in patient s pt s acute myocardial infarction AMI . Methods Thirty-two patients with AMI were t treated with urokinase ,and then divided into recanalization group and non2recanalization group. The levels of plasma ET- 1 ,NO ,hs2CRP , TXA2 were measured. Results The levels of plasma ET- 1 , hs2CRP , TXA2 in t reatment group were higher P 0. 05 ,and NO level was lower than that in the cont rol group P 0. 05 . The levels of plasma ET- 1 ,NO ,hs2CRP ,and TXA2 in recanalization group were significantly increased ,and the peak was higher than that in non2recanalization group P 0. 05 .The peak values of ET- 1 ,hs2CRP ,TXA2 ,and NO in recanalization group were at 3 h af ter thrombolysis ,and that in non2recanalization group were at 5 h after thrombolysis. Conclusion ET- 1 ,hs2CRP , TXA2 and NO could be used as index for thrombolytic therapy in AMI. Key words :acute myocardial infarction ;thrombolytic therapy ;endothelin- 1 ;high sensitive C2reactive protein