MMP_2_MMP_9在肺癌中的_省略_达及其与肺癌转移和预后关系的研究_薛洋.pdfVIP

2008, 23 (2)　CN 51-1356/R 225 [] 1002-0179 (2008)02-0225-03 MMP-2、 MMP-9 A Study on the Relationship Between Expression of MMP-2, MMP-9 and Metastasis and Prognosis in Patientswith Lung Cancer 1 2 3 3 薛洋 , 周清华 , 张尚福 , 刘伦旭 XUE Yang, ZHOU Qing-hua, ZHA NG Shang-fu, et al . (1., 　610072;2.; 3., 　610041) (1.TheDepartment of CardiothoracicSurgery , Sichuan ProvincialPeoples Hospital, Chengdu, Sichuan 610072, China; 2.TheDepartment of Cardiothoracic Surgery, Tianjin Medical University GeneralHospital, Tianjin 300052, China; 3.West China Hospital, Chengdu Sichuan 610041, China) 　　:: (NSCLC)-2 (MMP-2)-9 (MMP-9)。: (LSAB )108 19 MMP-2、 MMP-9 。:(1)MMP-2、 MMP-9 (P0.01)。(2)/ MMP-2、 MMP-9 /(P0.01 P0.05)。 (3)MMP-2、 MMP-9 (P0.01)。 (4) MMP-2、 MMP-9 (P0.05)。 (5)COX :MMP-2、 MMP-9 。:(1) MMP-2、 MMP-9 , 。(2)MMP-2、 MMP-9 (P0.05)。 (3)MMP- 2、 MMP-9 , 。 :;;;; [] R734.2　　　 [] A Abstract:Objective:To st dy the relationship between expression of MMP-2 MMP-9 and metastasis and prognosis in pa- tientswith l ng cancer.Methods:The expression of MMP-2 and MMP-9 were detected in 108 non-small cell l ng cancer tis- s es and 19 benign p lmonary lesion tiss es by imm nohistochemistry method (LSAB method).Res lts:(1)the expression of MMP-2, MMP-9 in l ng cancer tiss eswas significantly higher than that in adjacent non-cancero s l ng tiss es and benign p lmonary lesion (P0.05). (2)Compared to the cases witho t lymph node and/or distant metastasis, the expressions of MMP-2 and MMP-9 were significantly higher in caseswith lymph node and/or di