氧化苦参碱存0．9％NaCl溶液中溶解的热动力学性质.pdfVIP

CHINESE JOURNAL OF CHEM ICALPHYSICS VOLUM E 24，NUM BER 1 FEBRUARY 27，2011 ARTICLE ThermodynamicsPropertiesofOxymatrinein NaCISolution Zong—xiaoLi。，Xiao—huaPu。，W ei—weiZhaob YahChen。 ， a．DepartmentofChemistryandChemicalEngineer,BaojiUniversityofArtsandScience，Baoji721013 China b．CollieofScience，NorthwestAFUniversity,Yangling 712100，China (Dated：ReceivedonSeptember1，2010；AcceptedonOctober8，2010) Theenthalpiesofdissolutionofoxymatrinein0．9％NaClsolutionweremeasuredusinga RD496—2000CalvetMicrocalorimeterat309．65K underatmosphericpressure．ThediH-eren— tim enthalpyandmolarenthalpyofoxymatrinedissolutioninthe0．9％NaClsolutionofwere determined．Thecorrespondingkineticequationthatdescribedthedissolutionprocesswas elucidated．Moreover，thehalf-life，molarentropy，molarenthaply，andGibbsfreeenergyof thedissolutionprocesswerealsoobtained． Keywords：Oxymatrine，Thermodynamic，Kinetics，0．9％NaC1solution I．INTR0DUCT10N molarentropyAso1‰ ，GibbsfreeenergyAso1Gm，and molarenthaplyAso1Sm ofthedissolutionprocesswere Oxymatrineisoneofthequinolizidinealkaloidsex- obtained．Thisworkmayprovideapotentialreference tracted from the root oftraditionalC：hinese herbal fortheclinicalapplicationofoxymatrine． medicineSophorajaponica (SophoraFlavesccsnAit) f1]．Thechemicalstructureofoxymatrineisshownin Fig．1． Aswecan see，therearetwo nitrogen atoms 11．EXPERIM ENTS in themolecule．one asan amide and anotherbind— ingwithanoxygenatom toof．rm acoordinationbond． Oxymatrinewaspurchasedfrom BaojiFangshengBi— Thismodeofthebondresulted in itselectron supply— ologicalDevelopmentCo．，Ltd．(purity：98％)．NaC1 ing capacity weakened．so itsalkalineweakened，but wasanal