慢性阻塞性肺疾病患者的血清瘦素水平及其影响.docVIP

慢性阻塞性肺疾病患者的血清瘦素水平及其影响 　　作者：宋玉玲, 陈燕, 李鸿霞 作者单位：(新疆克拉玛依市中心医院科教科, 呼吸科， 新疆克拉玛依834000) 　　【摘要】目的：探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease COPD)患者血清瘦素的水平和意义。方法：观察COPD稳定期患者95例，其中营养不良45例，营养正常50例，以30例年龄相当的健康者作为对照。血清瘦素及肿瘤坏死因子Α(TNFΑ)水平采用间接酶联免疫吸附(ELISA)法测定，比较不同营养状况患者之间及其与健康者间各参数的差异，瘦素与各参数的相关性。结果：COPD病人的营养状况明显较健康对照者差，营养不良的发生率高(47.37%);COPD营养不良组、COPD营养正常组及健康对照组3组的瘦素水平依次升高[(5.34±3.31)ng/ml、(9.81±5.85)ng/ml、(14.12±9.39) ng/ml];而TNFΑ水平依次降低[(102.11±89.71)pg/ml、(31.85±30.63)pg/ml、(6.04±4.06)pg/ml]，差异有显著性(P0.05)。COPD病人的血清瘦素水平与体重、BMI、PAB、TSF、MAC、MAMC等均有相关性，但未发现与TNFΑ有相关性。结论：瘦素是一个与营养相关的蛋白质，在稳定期时其生理调节作用仍存在，与TNF无明显相关。 　　【关键词】 慢性阻塞性肺疾病; 瘦素; 营养障碍 　　The significance of serum leptin levels in patients with COPD 　　SONG Yuling, CHEN Yan, LI Hongxia 　　(Department of Respiratory Medcine, The Central Hospital, Karamy, Xinjiang 100083, China) 　　Abstract: Objective: To explore the significant of serum leptin levels in patients with chronic obstructive pulmonary disease(COPD). Methods: Nintyfive patients with COPD were devided into two groups based on body composition assessment (BCA) methods： group with malnutrition, group with normalnutrtion. Serum leptin and tumor necrosis factor alpha (TNFΑ) concentrations were measured by ELISA in 95 patients with COPD and 30 agematched healthy contrals. The difference of nutritional parameters between COPD patients and healthy controls were compared and the correlation of serum leptin and others parameters was analysed. Results: The nutritional status was significantly worse in the COPD patients than in the healthy controls. The rate of nutritional depletion was higher in COPD patients than in healthy controls (47.37% versus 0%). In COPD patients with malnutrition, COPD patients with normalnutrtion and healthy contrals, serum leptin levels were gradually increase：(5.34±3.31)ng/ml, (9.81±5.85)ng/ml, (14.12±9.39) ng/ml respectively; and TNFΑ were gradually decreased：(102.11±89.71)pg/ml, (31.85±30.63)pg/ml, (6.04±4.06) pg/ml