制备工艺对柴苓汤颗粒抗大鼠慢性肾功能衰竭的影响研究.pdfVIP

制备工艺对柴苓汤颗粒抗大鼠慢性。肾功能衰竭的影响研究△ 吴剑峰1★，曾煦欣地，詹海涛1，刘应时1(1．佛山科学技术学院医学院，佛山市528000；2．南方医科大学，广州 市 510515) 中圈分类号 R283；R96文献标识码 A 文章编号 1001一0408(2008)21—1606-03 摘要 目的：考察不同工艺制备的柴苓汤颗粒抗大鼠慢性肾功能衰竭(CRF)的效果。方法：给药组与模型对照组大鼠用腺嘌呤诱 发CRF．给药组分别给予日本津村、仿日本工艺与习用工艺颗粒，模型对照组与健康对照组给予生理盐水，观察尿、血生化指标以 及肾脏病理学形态变化。结果：与模型对照组比较，日本津村组、仿日本工艺组的血尿素氮、血总蛋白、血胆固醇、尿蛋白含量与肾间质损 或P0．05)。结论：津村与仿日本工艺柴苓汤颗粒对CRF大鼠的治疗作用馋于习用工艺柴苓汤颗粒。 关键词柴苓汤颗粒；慢性肾功能衰竭；制备工艺；影响 C盯atiVeEff∞tsof D∞oction Diffe他nt forChmnic C蛔iling P他pamtion1khnology Granul黜PMpar酣by RenaIFailureinRats WU ofFbshan Xu·xin，ZHANHai．tao，LIUYing—shi(MedicalCollege Jian—feng，ZENG 528000，China) ZENGXu．xin(southemMedical 510515，Chim) UniverSity，Guangzhou ABSTRACT thecurativeeffectofdifferent de00ction chronicre舱l 0BJE(TIVE：Tostudy Chailing granul∞on failu托(CRF) inrats．METHODS：SDratsintriaI andmodeI were adeninetoinduceCRFmodeI．Thetrial were groups groupgiven groups tr曲tedwith Chine驼∞mlalmethod Japane鸵Tsumuragranules，imitatingJapane鸵methodgranul鹤or thecontrolweretreatedwithsaline．The biochemical wellas of and urine，blood morphologicalchange group group par锄ete糟as were withmodel and method monitored．RESUL，rS：C咖pared granulesimitatingJapanese kidney group，Japane∞Tsumura reducedthelevelsofblood total cholesteroland the granulessignificantly ureanitrogen-serumprotein，鸵rum urinaryprotein，and was method at20tim骼doses