透皮给药后吡喹酮在小鼠体内组织分布和药代动力学_唐山枫.pdfVIP

2007, 15(5): 25-27 Chinese Journal of Veterinary Parasitology # # 透皮给药后吡喹酮在小鼠体内 组织分布及药代动力学 唐山枫, 胡小风, 郑新生 (, 430070) : 研究透皮给药后吡喹酮在小鼠体内的组织分布及药代动力学 用 200m g/mL吡喹酮透皮剂 涂擦小鼠腹部后, 用高效液相色谱法检测各时间点小鼠器官(肝心脏脾和肾)的吡喹酮浓度, 分析其在各器官 药代谢动力学特点 透皮给药后吡喹酮在小鼠肝脏分布浓度最高, 脾和肾次之, 心脏的浓度最低吡喹酮 在小鼠肝脏脾和肾脏 c- t曲线, 各出现两 个峰值, 第一个峰值 4m in, C 分别为 31. 78L g/mL和 7. 87Lg /mL, 第二 max 个峰值 15m in, C 分别为 27L g/mL, 11. 1L g/mL小鼠心脏的 c- t 曲线, 有 一个峰值 3m in, C 3. 1L g/mL m ax m ax 吡喹酮透皮给药后, 在小鼠肝脏分布浓度高, 达到了临床治疗的要求 : 吡喹酮; 透皮给药; 组织分布; 药代动力学 : S85 . 7 5 : A : 1005-0868( 2007) 05-0025-03 THE DISTRIBUTION AND PHARMACOKINETICS OF PRAZIQUANTEL AFTER TRANSDERMAL DRUG DELIVERY IN MOUSE TANG Shan-feng, HU X iao-feng, ZHENG X in-sheng (H ua Zhong Ag r icultural Un iv ersity Sc ience Colleg e, W uhan 430070, Ch ina) Abstr ct: Objective In order to study the tissue d istribution ofPraziquantel( PZQ) and the pharmacokinetics after transdermal drug delivery. M ethods PZQ w ere daubed on the belly of the m ice, wh ich concentration is 200Lg/mL. Then the concentration of PZQ w ere determ ined w ith HPLC in d ifferent tissue of heart, liver, k idney and sp leen and the pharmacok inetics of tissuesw as analysed. Results The concentration of liverw as highest, fo-l low ed by the sp leen, k idney and heart. The curves of the tissues ( liver, sp leen and k idney) had wt o zen iths. The first C appeared at and the second C is 27L g/mL and 11. 1Lg/mL at the tmi e of 15 m inutewh ile the curve of m ax max hear