放射性肾图检查的影响因素.pdfVIP

2 : 93 on-like granules and viral inclusion bodies could be found in th e cytoplasm of M s C. Bot h ribavirin an d f oscarnet cou ld inh ib it th e rep licat ion of HFRSV in M sC and t he earlier t hey w ere added th e st ronger t he viru ses w ere affect ed. We con clude t hat HFRS V can infect M sC and replicate in it. Viral inclusion body is one mode of viral pat hogenes is . M sC w ill change it s st ruct ure and fun ction w h en HFRS V invades . T his m ay be one of t he most import an t cau ses of acut e renal f ailure of HF RS. Ribavirin and foscarnet can inh ibit the replication of HFRSV -A9 st rain in M s C. T hese dat a provide experim en tal evidence for th e clin ical use of ant iviral t reatm ent in th e early s tage of HFRS. Key wordshemorr hag ic fev er w it h renal syndr o me; mesangial cell; r ibavirin; foscarnet 钱　瑛 ( 210029) ; B 2 000 13 1 131 -( - ) I I O IH 13 1 I-O IH 1 ( b ) ( c ) 1 35