复件复件重要的野马追对左氧氟沙星在小鼠气管粘膜内浓度的影响.docVIP

野马追对小鼠气管冲洗液中左氧氟沙星浓度的影响 张斯汉 周远大 何海霞 （重庆医科大学附属第一医院临床药理研究室，重庆，400016） [摘要]目的：探讨野马追对小鼠气管冲洗液中左氧氟沙星浓度的影响 方法：50只小鼠随机分为空白、氯化铵、野马追大、中、小剂量组，每组10只，分别给予生理盐水30 mL/kg、氯化铵1.00 g/kg、野马追大剂量64.45g(生药)/kg、中剂量32.73 g(生药)/kg、小剂量16.36 g(生药)/kg后1小时，各组动物腹腔注射左氧氟沙星0.07g/kg，2小时后处死动物，收集小鼠气管冲洗液，高效液相色谱检测其中左氧氟沙星浓度。结果：野马追大、中、小剂量组小鼠气管冲洗液中的左氧氟沙星浓度分别约为空白组小鼠的4.58、3.18、1.86倍。结论：野马追能提高小鼠气管冲洗液中左氧氟沙星的浓度。 [关键词]：野马追；左氧氟沙星；小鼠；气管；浓度 [中国图书分类法分类号]R969.2 文献标识码 A The Effect of Yemazhui on Concentration of Levofloxacin in Rinse Solution of Mice Tracheae Zhang si-han,Zhou yuan-da,He hai-xia (Clinical pharmacology laboratory of the first affiliated hospital of Chongqing university of medical sciences, Chongqing, 400016) [Abstract] Aim :to study the effect of Yemazhui on concentration of levofloxacin in rinse solution of mice tracheae. METHODS： were randomly divided into blank group、amchlor、emazhui large-dose group、emazhui middle-dose group、emazhui low- dose group,each group had 10 mice. After administration of liquor natrii chloridi isotonicus(NS) 30 mL/10kg、amchlor、emazhui large dose64.45 g(curde drug)/kg 、emazhui middle dose32.73 g(curde drug)/kg、emazhui low dose16.36 g(curde drug)/kg, mice were intraperitoneal injected Levofloxacin at dosage of 0.07 g/kg 2 hours after administration.The concentration of Levofloxacin in excretion of mice tracheae was detected by HPLC. Results:comparion with blank group, concentration of Levofloxacin in excretion of mice tracheae of Yemazhui large- dose group、emazhui middle-dose group、emazhui low-dose group was 4.58times、3.18times、1.86times the amout of that.Conclusion: Yemazhui can enhance concentration of Levofloxacin in rinse solution of mice tracheae. [KEY WORDS]：yemazhuLevofloxacin; mice; tunica mucosa tracheae; concentration ( 野马追是菊科泽兰属植物轮叶泽兰Eupatorium lindleyanum DC的全草，多年生草本植物，分布于华东、华南、华北、东北及台湾等地，具有清热解毒、祛痰定喘、降血压的功效，用于治疗慢性气管炎、支气管炎、高血压病。野马追所含的有效成分包括：黄酮类（flavonoids），挥发油（aetherolea），生物碱（alkaloid）等[1]。—22 g昆明种小鼠60只，随机分5组，每组10只（剩余10只制备空白灌洗