正柴胡饮颗粒一步制粒工艺研究.pdfVIP

第 29 卷第 1 期 南通职业大学学报 Ｖｏｌ．29 Ｎｏ．1 ２０15 年 3 月 ＪＯＵＲＮＡＬ ＯＦ ＮＡＮＴＯＮＧ ＶＯＣＡＴＩＯＮＡＬ UNIVERSITY Mar. ２０15 南 通 职 业 大 学 学 报 ２０15 年 !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! doi:10.3969/j.issn.1008-5327.2015.01.018 正柴胡饮颗粒一步制粒工艺研究 闫玉梅，秦 建，彭瑞潭，冒兴建 （精华制药集团股份有限公司 ， 江苏 南通 226005 ） 摘 要 ： 建立和优化中药正柴胡饮颗粒一步制粒的工艺路线和工艺参数。采用单因素考察法，以颗 粒成品率为评价指标，对药液相对密度、进风温度、雾化压力、喷雾速率等工艺参数进行考察。研究表 明，药液相对密度为1.15，进风温度为90 ℃ ，雾化压力0.4 MPa ，喷雾速率为2.0 L/min 条件下，制得 颗粒成品率较高，形态较好；用一步制粒法制备正柴胡饮颗粒，工艺参数稳定，值得在生产中应用。 关键词 ： 正柴胡饮颗粒；一步制粒；单因素考察 中图分类号 ： R283 文献标志码 ： A 文章编号 ： 1008-5327（2015 ）01-0072-03 A Study on One-step-granulating Process for Zheng-chaihu Granules YAN Yu-mei, QIN Jian, PENG Rui-tan, MAO Xing-jian (Jinghua Pharmaceutical Group Co., LTD, Nantong 226005, China) Abstract: Optimizing and establishing process route and parameters with one-step granulating technology is to produce traditional Chinese medicine Zheng-chaihu granules. With the method of single factor investiga－ tion, the paper takes finished product ratio of granule as evaluation index to investigate process parameters such as relative density of liquids, inlet air temperature, spray pressure, and spray rate. It is proved that we may get higher finished product ratio and superb morphology of granule with relative density of liquids of 1.15, inlet-air temperature of 90 ℃, atomization pressure of 0.4Mpa, spray-rate under 2.0L/min.The result in－ dicates that one-step granulation technology to produce Zheng-chaihu granules has outstanding advantages and it is worthy of applying into production. Key words: Z