酵母细胞凋亡机制研究进展.pdfVIP

8 6 V o.l 8 N o. 6 2010 11 Ch inese Journa l o f B ioprocess Eng ineer ing N ov. 20 10 do:i 10. 3969 .j issn. 1672- 3678. 2010. 06. 0 13 1, 2 1 1 1 1 吴 静 , 闵 柔, 雷艳丽, 邬敏辰, 陈 伟 ( 1. 江南大学 医药学院, 无锡 214122; 2. 江南大学 工业生物技术教育部重 实验室, 无锡 2 14122) : 凋亡是一种主动有序发生受多基因严密控制的细胞逐渐死亡过程, 对维持机 正常的生命活动发挥着重 要作用, 酵母因能发生细胞凋亡且凋亡机制与哺乳动物细胞相比具有高度保守性而成为研究细胞凋亡的重要模式 生物综述近年来酵母细胞凋亡的关键调节因子启动机制和信号通路的研究进展, 并展望其潜在应用前景 : 酵母; 细胞凋亡; 调节因子; 启动机制; 信号通路 : Q 935 : A : 1672- 367 8( 2010) 06- 0067 - 06 R esearch progress of yeast cell apop tosis and its m echan ism 1, 2 1 1 1 W U J ing , M IN Rou , LE I Y anl,i WU M inch en , CH EN W ei ( 1. Schoo l o f M ed icine and P ha rmaceutics, J iangnan U n iv ers ity, W ux i 2 14122, Ch ina; 2. K ey L aboratory o f Indu str ia l B io techno logy o f the M inistry of Education, J iangnan U n iversity, W ux i 214 122, Ch ina) Abs tract: The apoptosis is an active and orderly cell death process, t igh tly contro lled by m u ltiple genes. It plays an mi portant role on the body to m a intain no rm al life activities. Y east is the sing le cell eukaryo te that can be induced to undergo apoptosis, the m echanism o f apoptosis in ce lls from yeast to m amm als is h igh ly conserved, so the yeast has becom e an mi portant research mode l organism. In th is rev iew, the yeast is used as the mode l organism, and the stud ies on the key regu lator of yeast apoptosis, the activat ion m ech an ism and signa l pathw ays are summ arized. F inally, the p