用统计学特征预测蛋白质及RNA结合点位.pdfVIP

2010 International Conference on Services Science, Management and Engineering Predicting Protein - RNA Binding sites using statistical characters Liu Xinmi/Gong Xiujun/Zhao Feifei Dept. Computer Science and Technology Tianjin University Tianjin, China liuxinmi1104@tju.edu.cn Abstract—Protein and RNA interactions play essential roles in a number of biological regulatory mechanisms. Effectively identity the binding interfaces can help understand the interaction. In this paper, we took statistical information into account, mainly the singlet propensity and doublet propensity, and added the two propensities with the sequence information, using machine learning method to predict the interfaces. Results showed that adding statistical characters can improve the prediction precision, especially the doublet propensity. Besides, we constructed three more data sets based on the protein-RNA complex function, and found out for the first time that different complex function data sets show significant differences in prediction precision. Keywords-protein RNA interaction;singlet propensity;doublet propensity;machine learning;protein-RNA function 用统计学特征预测蛋白质与 RNA 结合点位 刘新觅，宫秀军,赵菲菲 天津大学计算机科学与技术学院，天津，中国，300072 liuxinmi1104@tju.edu.cn, gongxj@tju.edu.cn，zhaofeifei@tju.edu.cn 【摘要】理解蛋白质与 RNA 相互作用对破解许多生物学调控机制有重要作用。有效的识别绑定接口残基是理 解作用机制的重要方法。本文充分考虑了接口残基的统计偏好信息，主要是单个接口残基偏好性和成对接口 残基偏好性，并使其与氨基酸序列特征相结合，采用机器学习的分类方法来进行接口识别。实验结果表明加 入统计偏好