富血小板血浆治疗慢性组织损伤研究进展.pdfVIP

754 Chinese Journal of Reparative and Reconstructive Surgery, June 2010, Vol. 24, No.6 · · • 综 述 • 富血小板血浆治疗慢性组织损伤的研究进展 刘骥 袁霆 张长青 【摘  要】 目的 介绍富血小板血浆（platelet-rich plasma ，PRP ）及其在慢性组织损伤治疗中的作用。  方  法 检 索近年来国内外关于PRP 在慢性组织损伤治疗应用方面的文献，并进行总结。  结果 PRP 中的血小板和各类生长因子 以及它们之间的相互作用，通过各种作用途径，能促进多种慢性组织损伤的修复。但目前尚缺乏标准化的临床试验以推 广其应用。  结论 PRP 在慢性组织损伤的治疗中有望得到更广泛的应用。 【关键词】    富血小板血浆 慢性组织损伤 肌腱 软骨 研究进展 中图分类号： R318.08 R331.143 文献标志码：A RESEARCH PROGRESS OF PLATELET-RICH PLASMA IN TREATING CHRONIC TISSUE LESIONS/LIU Ji, YUAN Ting, ZHANG Changqing. Department of Orthopaedics, the Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China. Corresponding author: ZHANG Changqing, E-mail: zhangchangq@ 【Abstract 】 Objective To introduce the effect of platelet-rich plasma (PRP) in the treatment of chronic tissue lesions. Methods The latest research papers concerning the relevant subject were reviewed and analyzed. Results In PRP, the platelets and cytokines, the interaction of them in the same proportion as they were in the body fluid, played promoting role in repairing the chronic damage of tissues. However, there was still way to go before PRP was applied for clinical use in a wider range. Conclusion PRP has quite a bright outlook in the treatment of chronic tissue lesions. 【Key words 】 Platelet-rich plasma Chronic tissue lesion Tendon Cartilage Research progress [2] 相对于骨、肌肉等组织的急性损伤，由于软骨、韧 和骨骼矿化具有重要意义 。例如，PDGF 能促进结 [3] 带具有不可再生性和低代谢率，其受损后恢复缓慢。 缔组织细胞的有丝分裂 ；TGF 是重要的转化因子，同