泌尿系肿瘤干细胞的研究进展.pdfVIP

中国组织工程研究 第 16 卷 第32 期 2012 –08 –05 出版 Chinese Journal of Tissue Engineering Research August 5, 2012 Vol.16, No.32 泌尿系肿瘤干细胞的研究进展★ 刘 煜，苟 欣 Research progress of cancer stem cells in urologic cancers Liu Yu, Gou Xin 文章亮点： Department of 随着对肿瘤干细胞生物学、表面特异性标志物、相关信号转导通路及基因靶位研究的深入，针对肿瘤干细胞的靶向治 Urology, the First 疗将成为临床治愈肿瘤的一个重要途径。 Affiliated Hospital of Chongqing Medical University, Abstract Chongqing 400016, China BACKGROUND: Although the research about the cancer stem cells from urologic cancers is late, it also makes some Liu Yu★, Studying for achievements. master’s degree, Department of OBJECTIVE: To review the research progress of urologic cancer stem cells in recent years. Urology, the First Affiliated Hospital of METHODS: Articles related to the research progress of urologic cancer stem cells in PubMed database from January 1997 to Chongqing Medical August 2011 were retrieved by the computer with the key words “cancer stem cell, urologic cancer”. A total of 289 articles were University, obtained from the database. The repetitive articles and non-compliant articles were excluded, and finally 30 articles were included Chongqing 400016, China for further analysis. tommyliuyu@ RESULTS AND CONCLUSION: As the in-depth study of cancer stem cells, more and more cancer stem cells have been identified and isolated from kinds of tumors, and cancer stem cells in urologic cancers have acquired some advancement. Their biological Corresponding author: Gou Xin, characteristics, self-regulatory mechanisms and micro-environment are further understood by researches, and cancer stem cells Professor, Chief targeted therapy will become a new way for curing urologic cancers in the future. physician, Department of Urology, the First Liu Y, Gou X. Research progress of canc