齐拉西酮血浆浓度和其治疗精神分裂症临床效应的相关性分析.pdfVIP

齐拉西酮血浆浓度与其未厶垂； J ，口7 精神分裂症临床效应的相关 性分析木 翟 杰徐淑祝王广银崔吉俊马玉真 宋杰孙呈勇 【摘要】 目的探讨齐拉西酮在中国精神分裂症患者体内的血药浓度与临床疗效的关系。方法 采用高效液 (PANSS)评分，用SPSSl7．0统计软件包对血药浓度与疗效评分进行统计分析。结果治疗第2、6、12周末 差异有统计学意义(P0．05)。结论结果支持齐拉西酮血浆浓度与其对精神分裂症阴性症状临床疗效相关。 其血浆浓度88¨g／L时，疗效较好。 【关键词】 齐拉西酮精神分裂症血浆药物浓度相关性检验 【中图分类号】R749．3【文献标识码】 A 【文章编号】 and in Correlationbetween concentrationof clinical analysis plasma ziprasidone efficacy schizophrenia．ZHAIJie，XUShuzhu，WANG of Petroleum Guangyin，eta1．ShengliHospitalShengli 257055，China Bureau，Dongying Todeterminethe between concentrationof anditsclinical 【Abstract】0bjective relationshipplasma ziprasidone inthe determinedwith treatmentof concentrationwas HPLC． efficacy plasma schizophrenics．MethodsZiprasidone was Clinical wasassessedwith and usedto the scale(PANSS)．SPSSl7．0 efficacy positivenegativesyndrome explore Therewere between concentrationandclinical no relationshipziprasidone efficacy．Results plasma between concentrationandthe rateof at and12thweekend correlation PANSSthe ziprasidoneplasma reducing 2nd，6th ofthe concentrationwas correlatedwiththe rateofSANS treatment．Ziprasidoneplasma significantlypositively reducing