加替沙星分散片处方及制备工艺研究.pdfVIP

加替沙星分散片处方及制备工艺研究 姚敦武lq。，何清林2 410014；3．湖南省中医药研究院中药研究所，长沙市410013) 文献标识码 A 中图分类号TQ460．6；R944．4 文章编号 100卜0408(2006)09-0659-04 摘要 目的：考察及筛选加替沙星分散片的制备工艺和最优处方。方法：通过系列试验筛选崩解剂等辅料，确定处方及制备工艺； 测定并比较了分散片及普通片剂中主药的溶出度。结果：确定了以羧甲基淀粉钠、交联聚乙烯吡咯烷酮作为崩解剂的分散片处方； 分散片溶出速度较普通片更快。结论：研制的加替沙星分散片处方合理、工艺可行，符合分散片的质量要求。 关键词加替沙星；分散片；处方；制备工艺 ofFormulaand TechnicsofGatifloxacin Tablets Optimization Preparation Dispersible YAO ProvincialTumor 410013，China) Dunwu(Dept．ofPharmacy，Hu’nan Hospital，Changsha HE InstituteofPharmaceutical Qinglin(Hu’nan Industry，Changsha410014，China) XIAO InstituteofChineseMateria of Dehua(Hu’nan Medica，AcademyTCM，Changsha ABSTRACT the OBJECTIVE：To technicsandtheformulaof tablets． optimizepreparation gatifloxacindispersible METHODS：Theuvantlike etc．，theformulaand were aseriesof adj disintegrant preparationprocessoptimizedby experi— ments．Thedissolutionratesofthe in tabletandconventionaltabletweredeterminedand principalagentdispersible compared． RESULTS：Sodiumstarchand were asthe ofthe carboxymethylcrospolyvinylpyrrolidonedisintegrants optimized tabletformula；Thedissolutionrateofthe tabletwasfasterthanthatoftheconventional dispersible The tabletisreasonablein in anditmeetsthe standards． preparedgatifloxacindispersible formula，feasibletechnology quality KEY WORDS technics Gatifloxacin；Dispersibletablets；Formula；Preparation 喹诺酮类抗菌药物是近年来发展较为迅速的一类抗菌药 喹诺酮类药，其抗菌谱广，对革兰阳性菌、革兰阴性菌、厌氧菌 物，目前在国内、外已上市的品种达20余种，加替沙星为