非抗生素物质抗菌治疗的研究现状.pdfVIP

· 592 · 临床儿科杂志 第 33 卷第 6 期 2015 年 6 月 J Clin Pediatr Vol.33 No.6 Jun. 2015 doi ：10.3969 j.issn.1000-3606.2015.06.023 ·文献综述· 非抗生素物质抗菌治疗的研究现状 龙　智 　周云芳 综述 审校 上海交通大学医学院附属上海儿童医学中心感染科( 上海　200127) 摘要：　随着抗生素不合理使用的增多，细菌耐药的形势越来越严峻，多重耐药(MDR)细菌的报道屡见不鲜，给 临床感染治疗带来了极大的困难。为了治疗MDR细菌引起的感染以及减少耐药菌的产生，研究人员正积极研究非抗生 素物质的抗菌治疗策略。文章综述其中已证实具有疗效的噬菌体、金属及金属螯合剂、免疫疗法、光动力疗法、一氧化 氮、小分子化学抑制剂、生物肽、中药等的研究现状。 关键词：　多重耐药菌；　非抗生素治疗；　抗菌作用 Current research status of non-antibiotic antibacterial therapies Reviewer: LONG Zhi, Reviser: ZHOU Yunfang ， ， (Department of Infection Shanghai Children s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine ， ， Shanghai 200127 China) Abstract: With the inappropriate use of antibiotics, the situation of bacterial resistance is more and more severe. The emergence of multidrug-resistant (MDR) bacteria has made it difficult to cure the infections in clinical. For treatment the infections caused by MDR and reducucton of the generation of resistant bacteria, researchers are actively studying on the non- antibiotic substances for antibacterial activity. In this paper, the advances in those with confirmed effects such as phage therapy, metal/chelation therapy, immunization therapy, photodynamic therapy, and nitric oxide (NO)-based therapies, small molecule inhibitors, antimicrobial peptides and Chinese herb were reviewed. Key words:　multi-drug resistant bacteria;　non antibiotic;　antibacterial activity 近年来，随着抗生素不恰当使用的增多，细菌的耐药形势 细菌感染性疾病。 越来越严峻，多重耐药(multi-drug resistant ，MDR)细菌的报道