Effects of interleukin-33 on cardiac fibroblast gene expression and activity外文翻译.pdfVIP

Cytokine 58 (2012) 368–379 Contents lists available at SciVerse ScienceDirect Cytokine journal homepage: www.elsevier .com/locate/ issn Effects of interleukin-33 on cardiac fibroblast gene expression and activity Jinyu Zhu, Wayne Carver ⇑ Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, United States a r t i c l e i n f o a b s t r a c t Article history: Interleukin-33 (IL-33) is a recently described member of the interleukin-1 (IL-1) family. It is produced by Received 13 September 2011 diverse cell types in response to a variety of stresses including hemorrhage and increased mechanical Received in revised form 26 January 2012 load. Though only relatively recently discovered, IL-33 has been shown to participate in several patholog- Accepted 15 February 2012 ical processes including promoting type 2 T helper cell-associated autoimmune diseases. In contrast, IL- Available online 23 March 2012 33 has been also found to have protective effects in cardiovascular diseases. Recent studies have illus- trated that IL-33 attenuates cardiac fibrosis induced by increased cardiovascular load in mice (transaortic Keywords: constriction). Since cardiac fibrosis is largely dependent on increased production of extracellular matrix Cardiac fibroblast Interleukin-33 by cardiac fibroblasts, we hypothesized tha