HER2 Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival外文翻译.PDFVIP

HER2 Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival 1 1 1 1 Subhasis Das , Gautam Sondarva , Navin Viswakarma , Rakesh Sathish Nair , Clodia Osipo2 3 4, 5 1, 5, * , Guri Tzivion , Basabi Rana and Ajay Rana 1Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL 60153; 2Department of Pathology, Loyola University Chicago, Maywood, IL 60153; 3Cancer Institute and Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216; 4Department of Medicine, Division of Gastroenterology Nutrition, Loyola University Chicago, Maywood, IL 60153; 5Hines VA Medical Center, Hines, IL 60141 *Running Title: Regulation of MLK3 by HER2 *To whom correspondence should be addressed: Department of Pharmacology, Bldg. 102, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA. Tel: 708-216-5761; Fax: 708-216-6596; E-mail: arana@ Key Words: Breast cancer, HER2, MLK3, JNK and AKT Background: Amplification of HER2 which HER2 promotes cell survival, we suppresses downstream pro-apoptotic noticed a profound reduction in the kinase pathways for breast cancer cell survival. activity of a pro-apoptotic mixed lineage Results: The pro-apoptotic MLK3 kinase kinase 3 (MLK3) in HER2 positive activity is suppressed by HER2. (HER2+) but not in HER2 negative (HER2-) Conclusion: MLK3 mediates HER2- breast cancer tissues, while both HER2+ and induced breast cancer cell viability. HER2- tumors expressed a comparable level