《Lipocalin2 Test in Distinguishing Acute Lung Injury Cases from Septic Mice Without Acute Lung Injury》.pdfVIP

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《Lipocalin2 Test in Distinguishing Acute Lung Injury Cases from Septic Mice Without Acute Lung Injury》.pdf

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Chin Med Sci J Vol. 29, No. 2 June 2014 P. 65-77 CHINESE MEDICAL SCIENCES JOURNAL ORIGINAL ARTICLE Lipocalin-2 Test in Distinguishing Acute Lung Injury Cases from Septic Mice Without Acute Lung Injury△ 1 2 1 1 Gao Zeng , Cong-wei Jia , Jie Liu , and Shu-bin Guo * 1Department of Emergency, 2 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100730, China Key words: lipocalin-2; acute lung injury; biomarker; sepsis; neutrophil gelatinase associated lipocalin Objective To explore whether the amount of lipocalin-2 in the biofluid could reflect the onset of sepsis-induced acute lung injury (ALI) in mice. Methods Lipopolysaccharide (LPS, 10 mg/kg) injection or cecal ligation and puncture (CLP) was performed to induce severe sepsis and ALI in C57 BL/6 male mice randomly divided into 5 groups (n=10 in each group): group A (intraperitoneal LPS injection), group B (intravenous LPS injection via tail vein), group C (CLP with 25% of the cecum ligated), group D (CLP with 75% of the cecum ligated), and the control group (6 sham-operation controls plus 4 saline controls). All the mice received volume resuscitati