Alginate$chitosan particulate systems for sodium diclofenac release.pdfVIP

International Journal of Pharmaceutics 232 2002 225–234 /locate/ijpharm Alginate/chitosan particulate systems for sodium diclofenac release M.L. Gonza′lez-Rodr?′guez a,*, M.A. Holgado a, C. Sa′nchez-Lafuente a, A.M. Rabasco a, A. Fini b a Departamento de Farmacia y Tecnolog?′a Farmacace′utica, Facultad de Farmacia, C/Profesor Garcia Gonzalez s /n, Uniersidad de Seilla, 41012 Seilla, Spain b Istituto di Scienze Chimiche, Uniersita` di Bologna, 40127 Bologna, Italy Received 25 June 2001; received in revised form 8 October 2001; accepted 11 October 2001 Abstract Alginate/chitosan particles were prepared by ionic gelation Ca2 + and Al3 + for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was brie?y discussed. ? 2002 Elsevier Science B.V. All rights reserved. Keywords: Alginate/chitosan beads; Ca2 + and Al3 + ions; Sodium diclofenac; Alginate/chitosan ratio; Dissolution pro?les 1. Introduction caprolactone Alonso et al., 2000 , poly-/vinylalco- hol Chawla et al., 2000 , poly-lactide-co-glycolide The use of biodegradable polymeric carriers for Tuncay et al., 2000a,b . Also natural polymers the drug delivery systems has gained a wide interest, found their application in this ?eld: albumin Tun- mainly for their biocompatibility and, among the cay et al., 2000a,b , alginate Gursoy and Cevik, microparticulate systems, microsphe