清热化湿方治疗慢性浅表性胃炎伴糜烂脾胃湿热证疗效观察和机理探讨.pdfVIP

Clinical Study on Qingre huashi Recipe in Treating spleen-stomach Damp-heat Syndrome of Chronic Superficial Gastritis with Erosion Speciality: Gastroenterology. Internal medicine of Integrated traditional Chinese and Western medicine Author: Sun Wenzheng Tutor: Prof. Yao Baotai Abstract Objective: To explore the therapeutic effect, mechanism and safety of Qingrehuashi recipe in treating chronic superficial gastritis with erosion pertaining to spleen-stomach damp-heat syndrome. Methods: 60 cases of chronic superficial gastritis with erosion were divided into two groups randomly. The treatment group and control group, both containing 30 cases, were treated with Qingrehuashi recipe and Qingweizhitong granule orally for 8 weeks, respectively. The clinical,gastroscopy and pathological effects and Hp infection were observed before and after the course. Results: Both total effective rate and curative rate in the treatment group were superior to those in control group (93.33% and 43.33% vs 76.67% and 23.32%, P0.05). Conclusion: Qingre huashi recipe is effective and safe in intreating chronic superficial gastritis with erosion pertaining to spleen-stomach damp-heat syndrome. The mechanism might be related to anti-inflammation, anti-oxidative sterss, eradicating Hp and promoting gastric motility and enhancing gastric mucosal barrier. Key words superficial gastritis; erotion; Qingrehuashi recipe; spleen-stomach damp-heat syndrome 目 录 引 言 1 临床研究 3 一、临床资料 3 （一）病例选择标准 3 （二）一般资料 7 二、治疗方法 8 （一）治疗组 8 （二）对照组 8 三、观察指标与方法 8 （一）安全性指标观测 8 （二）疗效性指标观测 9 四、疗效判定标准 9 （一）临床综合疗效标准 9 （二）中医证候疗效判定标准 10 （三）临床症状疗效评价标准 10 （四）胃镜、组织病理学疗效标准 10 五、统计学处理方法 11 六