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3．1各组大鼠心肌梗死面积的组间比较···························22
3．2各组大鼠血清NO及NOS含量的组间比较····················23
的组间比较··················································24
第三部分讨论·············································26
1．MI模型制备过程的常见问题与关键要点·······················26
2．NO及NOS在缺血性心肌病中的作用··························27
3．冠脉侧枝循环以及血管生成··································29
3．1冠状动脉侧枝循环·········································30
3．2血管生成·················································31
4．安心颗粒的研究基础········································32
4．1安心颗粒的立法依据·······································32
4．2安心颗粒的组方原则···········。···························34
4．3安心颗粒各组成药物对血清NO及NOS影响的实验研究········34
4．4安心颗粒的前期研究·······················-···············35
4．5安心颗粒促血管新生的机制·································36
5存在的问题与展望····················。·····················37
结幸{≥····················································39
参考文献····················································40
附l蛰····················································47
综 述····················································50
蜀【 谢····················································51
攻读学位期间发表的学术论文目录·····························59
作者声明···················，································60
个人简历···················································61
2
中英文缩略 词汇 表
英文缩写 英文全称 中文名称
AS Atherosclerosis 动脉粥样硬化
AXG Anxin 安心颗粒
granules
CHD heartdisease 冠状动脉性心脏病
Coromary
HDL．C Highdensitylipoprotein 高密度脂蛋白胆固醇
cholester01
MI infarction 心肌梗死
Myocardial
NO Nitricoxide 一氧化氮
oxide
NOS Nitric synthase
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