壳聚糖负载群地平药物缓释微球的制备及其性能.pdf

壳聚糖负载尼群地平药物缓释微球的制各及其性能 释药速率在酸性缓冲溶液中略大于碱性缓冲溶液中。 关键词：尼群地平，壳聚糖，海藻酸钠，戊二醛，交联，载药微球 ll 壳聚糖负载尼群地平药物缓释微球的制各及其性能 STUDIESONPREPARATIONSANDPROPERTIES OFNI田刚巳NDIPINECⅢTOSAN and Major：PolymerChemistryPhysics Name：SuJuan Supervisor：LiGuoming ABSTRACT tothe ofemulsificationandmacromolecule Accordingprinciple self-assemble， were emulsion Nitrendipine--chitosanmicrospherespreparedby cross··linking techniques、)l，itllglutadcdialehyde(GD)ascross—linking themodel andsizesofthe polymericcarrier，NitrendipinefNit)as drug．Theshapes werereviewed andlaser by microscope analyzer．The microspheres optical particle ofthe werecharacterizedFT-IRand physicochemicalpropertiesmicrospheres by XRD ofthe were analyses．Thedrug-releasingperformancesmicrospheres UV二VIS andinvitroreleasetests．Aseriesofstudiesand investigated by analyses areas result follows： Thechemicaland ofNitweretested．Theresultsindicate physical properties thatNithasallintricate curvesshowthe andTG fmgerprintregion，DSC melting of indicatesa of Nit，XRD point analysis hi曲crystaUinityNit，theabsorptionpeak ofNitatUV237nmcallbeastandardforits quantitativeanalysis．