硅基抗菌材料及抗菌应用基础研究.pdfVIP

II III 硅基抗菌材料及其抗菌应用基础研究 中文摘要 中文摘要 随着致病菌感染而造成的疾病种类的不断增加，发展具有高效抗菌性能的新 型抗菌材料引起了研究者们广泛的关注。在过去数十年时间内，各种各样的新型 抗菌材料被相继开发和制备。其中，银纳米颗粒由于其对细菌、真菌及病毒等多 种微生物的生长均具有良好的抑制作用而得到深入研究。值得关注的是，游离银 纳米颗粒因其稳定性较差，在溶液状态下容易聚集，导致其抗菌性能减弱，妨碍 了银纳米颗粒的实际应用。目前，研究者们通过将银纳米颗粒固定到基底上，从 而有效阻止了银纳米颗粒的团聚，保证了其抗菌性能的稳定性。在本文中，我们 首先将银纳米颗粒通过化学原位还原生长的方法固定在硅晶片表面，得到了表面 覆盖银纳米颗粒的硅晶片复合材料。在此基础上，将所得到的硅基复合材料作为 抗菌试剂，应用于较为详细的抗菌应用研究中。研究表明，该新型硅基抗菌材料 具有高效且稳定的抗菌性能，在室温条件下存储 30 天后仍保持对大肠杆菌 99%的 抑制活性。上述工作对于发展新型抗菌试剂具有较为重要的科学研究价值和潜在 的应用价值。 关键词：致病菌；硅晶片；银纳米颗粒；抗菌 作 者：周炎烽 指导老师：何 耀 教授 I Abstract Silicon-Based Antibacterial Material of Robust and High Antibacterial Activity Silicon-Based Antibacterial Material of Robust and High Antibacterial Activity Abstract With the increasing number of infectious diseases caused by different pathogenic bacteria, the studies are orientating towards development of new and effective antibacterial materials. In the past decade, many kinds of materials have been developed as novel kinds of antibacterial materials. Among them, AgNPs are of particular interest due to their strong antimicrobial activity toward a broad spectrum of bacteria, virus, and fungi. While free AgNPs are potentially high-quality antibacterial candidates, they generally possess poor stability and are prone to be aggregated in aqueous phases, leading to loss of antibacterial activity and hampering their practical applications. Various substrates have been employed to prevent AgNP aggregation by the formation of nanocomposites. While such AgNP-e