Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging》.pdf

M O L E C U L A R O N C O L O G Y 9 ( 2 0 1 5 ) 7 4 0 e7 4 8 avai lab le at w w w . s c i e n c e d i r e c t . c o m ScienceDirect /locate/molonc Technical Note Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging a, a a Sumitaka Hasegawa *, Yukie Morokoshi , Atsushi B. Tsuji , Toshiaki Kokubob a a a , Ichio Aoki , Takako Furukawa , Ming-Rong Zhang , Tsuneo Sagaa aMolecular Imaging Center, National Institute of Radiological Sciences, Chiba 263-8555, Japan bLaboratory Animal and Genome Sciences Section, National Institute of Radiological Sciences, Chiba 263-8555, Japan A R T I C L E I N F O A B S T R A C T Article history: Radiation-induced thymic lymphoma (RITL) in mice is induced by fractionated whole-body X- Received 13 September 2014 irradiation (FX) and has served as a useful model for studying radiation carcinogenesis. In this Received in revised form model, the initial postirradiation cellular events in the thymus and bone marrow (BM) are crit- 26 November 2014 ically important for tumorigenesis, and BM transplantation (BMT) prevents RITL. However, Accepted 26 November 2014 direct assessment of these events is so far restricted by the lack of noninvasive monitoring Available online 3 December 2014 technique