原创力文档Rational Daily Administration Times of Yinchenhao Decoction in Rats with Jaundice Based on PDPK》.pdf
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Rational Daily Administration Times of Yinchenhao Decoction in Rats with Jaundice Based on PDPK》.pdf
150 Lv JL et al. Chinese Herbal Medicines, 2012, 4(2): 150-156
Rational Daily Administration Times of Yinchenhao Decoction
in Rats with Jaundice Based on PD/PK
1, 2 1, 2 1* 1 1, 2 1, 2
LV Jun-lan , JIN Shi-ying , YUAN Hai-long , HAN Jin , FU Shan-shan , JIN Shi-xiao , GUO
Jing-jing1, 2, XIAO Xiao-he1*
1. China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China
2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611731, China
Abstract: Objective To study the rational daily administration times of Yinchenhao Decoction (YCHD) when it was used to
treat experimental jaundice in rats based on pharmacodynamics/pharmacokinetics model. Methods Rats were
modeled by 4% 1-naphthylisothiocyanate (75 mg/kg) for 48 h, then YCHD was drenched with doses of 0.324 g/kg
(extract, calculated with the clinical dosage) once, 0.162 g/kg twice, and 0.108 g/kg thrice a day, respectively. The
total bile and the flow rate of bile were observed after the first administration; Blood samples collected from the
orbital sinus at different intervals were used to investigate the levels of liver enzymes (ALT and AST) and bilirubins
(TBIL and DBIL), and determine the concentration of 6,7-dimethoxycoumarin (DME) in the plasma using UPLC at
the same time, then we obtained the time-effect and time-dose curves. The rational daily administration times of
YCHD when treating experimental jaundice were determined based on the comprehensive analysis of time-effect and
time-concentration rel
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