Recent advances in 4-hydroxycoumarin chemistry. Part 2 Scaffolds for heterocycle molecular diversity》.pdf

Arabian Journal of Chemistry (2015) xxx, xxx–xxx King Saud University Arabian Journal of Chemistry .sa REVIEW Recent advances in 4-hydroxycoumarin chemistry. Part 2: Scaffolds for heterocycle molecular diversity Moaz M. Abdou a,*, Rasha A. El-Saeed b, Samir Bondock b,c a Egyptian Petroleum Research Institute, Nasr City, P.O. 11727, Cairo, Egypt b Department of Chemistry, Faculty of Science, Mansoura University, ET-35516 Mansoura, Egypt c Department of Chemistry, Faculty of Science, King Khalid University, 9004 Abha, Saudi Arabia Received 5 December 2014; accepted 26 June 2015 KEYWORDS Abstract The present paper aims to review the synthetic applicability of 4-hydroxycoumarin in 4-Hydroxycoumarin; heterocyclic synthesis during the period from 1996 up to now. This compound can be used as build- Annelated heterocycles; ing blocks for five, six, and seven-membered heterocycles as well as fused rings. Multicomponent reactions; ª 2015 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access Green chemistry article under the CC BY-NC-ND license (/licenses/by-nc-nd/4.0/). Contents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 2. Synthesis of monocyclic heterocyclic compounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 00 2.1. Synthesis of five-membered systems with two heteroatoms . . . . . . . . . . . . . .