二至天癸颗粒对子宫内膜CTmRNA表达的影响.pdf

Erzhi Tiangui Granules on the influence of endometrial CTmRNA expression Speciality:Gynecology of TCM Author:Liu Zhuo Tutor: Professor Lian Fang Abstract Objective: To observe Erzhi TianGui granules (ETG)to IVF ready to cycle the influence of endometrial CTmRNA expression, and explore the mechanism of Tranditional Chinese Medcine(TCM)in improving controlled ovarian hyperstimulation(COH) endometrial receptivity. Methods: 70 infertile women undergoing In vitro Fertilization and Embryo Transfer(IVF-ET)were randomly divided into two groups. treatment group, pretreatmented with ETG of 1 cycles and after unite with gonadotropin (Gn)(35 cases) ，and control group， pretreatmented with Liuwei dihuang granules of 1cycles and then unite with Gn (35 cases)，In the pretreatmented period of about 21 days(Namely the implantation window), through patients with the informed consent to suck up a little of endometrial tissue,then in Eppendof tube for liquid nitrogen cans of freeze-stored,use RT-PCR, to testing CTmRNA temporal expression;then to evaluate the syndrome points of TCM ，thickness and type and volume of endometrium 、pulsatility index (PI)and resistent index (RI) of uterus artery,Serum hormone levels，Of follicular situation on the day of HCG injection were observed.Moreover,clinical pregnancy rates were compared between these two groups. Results: (1)There were statistical significance before and after the treatment in the syndrome points of Kidney-deficiency, But the treatment group than in the control group curative effect is distinct （P0.05 ）; （2 ）The follicular score、endometrial thickness、 endometrial volume on HCG day were sign