药理antianginal drugs.ppt

ANTIANGINAL DRUGS What’s the Angina Pectoris ? 分型 classifications ①劳累性心绞痛：可分为稳定型、初发型及恶化型心绞痛； ②自发性心绞痛 包括：卧位型、变异型、中间综合征和梗死后心绞痛； ③混合性心绞痛 The pathophysiology underlying angina pectoris major determinants of myocardial oxygen consumption: myocardial basic metabolism heart rate contractility wall tension ejection time blood pressure (peripheral resistance) The mechanism of antianginal drugs O2 increase supply and/or lower demand Myocardial O2 supply: Coronary blood flow, regional flow distribution Myocarial O2 –demand: amount of energy required to support the work of the heart Cardi