三种低氧训练方法对大鼠全脑cAMP及其内源性CO及其自由基代谢的影响.pdf

目 录 摘要······························································1 ABSTRACT ························································2 1 文献综述······················································4 1.1 内源性 CO 的产生及作用机制 ········································4 1.2 cAMP 的产生及作用机制 ···············································4 1.3 内源性 CO 在中枢神经系统中的作用及运动的影响 ····················5 1.3.1 内源性CO 对脑血流的影响··········································6 1.3.2 内源性 CO 对脑组织缺氧缺血性损害的影响·························6 1.3.3 内源性CO 在长时程增强 (LTP) 中的影响 ·····························7 1.3.4 内源性CO 在发热反应中的作用 ·····································7 1.3.5 内源性 CO 在疼痛感觉信号传递中的作用···························8 1.3.6 内源性 CO 变化对脑的影响 ········································ 8 1.3.7 血浆内源性CO 水平与脑内源性 CO 的关系 ························· 9 1.3.8 运动与内源性 CO 的关系········································· 9 1.4 cAMP 对中枢神经系统的作用及运动的影响 ·························· 10 1.4.1 cAMP 在长时程增强 (LTP)中的作用 ································ 11 1.4.2 cAMP 在脑缺血/再灌注损伤中的作用 ······························ 11 1.4.3 cAMP 对中枢神经系统兴奋性传递与抑制性传递的作用 ············ 12 1.4.4 cAMP 在体温调节过程中的作用 ···································· 12 1.4.5 cAMP 变化对脑的影响 ··············································13 1.4.6 运动对 cAMP 的影响 ··············································14 1.5 cAMP 与内源性 CO 变化对脑影响的综合分析························· 14 2 选题依据 ···········································15 3 实验研究 ················································ 16 3.1 实验对象···························································· 16 3.2 动物训练模型的建立················································ 17 3.3 低氧环境设备及其工作原理·········································18 3.4 样品采集 ···························································· 19 3.5 测试指标···························································· 19 3.6 指标测试方法······················································· 19 3.7 数据统计 ············································