《A STUDY ON THE TREATMENT OF GASTRIC CANCER BY CD GENE COMBINED WITH 5-FC IN VITRO AND IN VIVO》.pdfVIP

294 Chinese Journal of Cancer Research 13(4): 294-297, 2001 A STUDY ON THE TREATMENT OF GASTRIC CANCER BY CD GENE COMBINED WITH 5-FC IN VITRO AND IN VIVO 1* 2 2 2 Guo Shan-yu 郭善禹 , Gu Qin-long 顾琴龙 , Zhu Zheng-gang 朱正纲 , Lin Yanzhen 林言箴 1 Department of Surgery, The Affiliated Shanghai Ninth P eople ’s Hospital, Shanghai S econd M edical University, Shanghai 20001; 2 Department of Surgery, Shanghai Institute of D igestive Surgery, Ruijin Hospital, Shanghai Second M edical University, Shanghai 200025 CLC number: R735.2 Document code: A Article ID: 1000-9604(2001)-04-0294-04 ABSTRACT chemotherapeutic treatment against middle stage and advanced gastric cancer is not satisfactory. The gene Objective: To study the killing effect of suicide gene therapy started a new way to the treatment of CD on mouse gastric cancer. Methods: CD gene was malignant diseases. transduced with the retroviral vector. The killing effect The enzyme/prodrug system that increases the and bystander effect of CD gene on mouse gastric cancer drug sensitivity of tumor cells has emerged as an cell line MFC were observed. The mouse gastric cancer effective method of selective elimination of tumor model was used for in vivo study. The CD gene cells. This kind of drug sensitive genes includes the containing virus was injected i