《Phase Ⅱ clinical study on the modified DCF regimen for treatment of advanced gastric carcinoma》.pdfVIP

，2011；124(19)：2997-3002 2997 article Original II for PhaseclinicalonthemodifiedDCF study regimen treatmentofadvancedcarcinoma gastric Yihebali andWANGJin—wail Chi，REN Lin，CUI Jian-hong，YANGCheng—xu，LIJun—ling DCF Keywords：gastriccancer；modified A IIItrial the treatmentofadvanced Backgroundphase involvingdocetaxel，cisplatin，andfluorouracil(DCF)in gastric tohave to andfluorouracil cancerwasshown alone．butwitha rateof superiorefficacycomparedcisplatin high reduce while the of reducedthedosesof hematologictoxicity．TotoxicitymaintainingefficacyDCF,we administered5一fluorouraci acontinuous cis-platinum(CDDP)，and J(5-FU)via intravenous(CIV)infusion． Methods with adenocarcinomasreceived 1 houron Chemotherapy．naivepatientsgastric D(60mg／m2 day1)，CDDP 1 and h。。CIVon 1 and8 3 (30mg／m‘ondays 2)，and5-FU(1500mg·m-2．·24 days everyweeks)．Theprimaryendpoint wasthe rate． response the ResultsFourteenwereenrolled．Basedon evaluationatIeast2 of patients efficacy foIlowing cycles was 7．1％completeremission(CR)，71％partialremission(PR)，14％stabledisease(NC／SD)，and 1 mediansurvivaltimewas3months．Nine III-IV 4 disease(PD)．The