应用表面增强拉曼光谱检测水中抗生素地研究.pdf

The Study of Antibiotics Aqueous Solution using Surface-enhanced Raman Spectroscopy Abstract Since the first antibiotic discovered in 1928, antibiotics are widely used in the control of bacterial diseases of humans, livestock and aquatic animals. At the same time, the antibiotic was found to have a lot of harm to human health and the environment. Many antibiotics for humans have toxic reaction, and abuse of antibiotics lead to drug-resistant . Many countries in the world have introduced policies to prohibit or restrict use of antibiotics. But the reality is that abuse of antibiotics in aquaculture is not disappear despite repeated prohibitions, the detection of antibiotic residues in culture water is imperative. The antibiotic residue detection methods have defects respective, their use is restricted. The standard detection method commonly used in China is high-performance liquid chromatography (HPLC) with high sensitivity. But the operation of HPLC is a long tedious and time consuming, and discomfort for the rapid analysis of a large number of samples and live detection. Surface-enhanced Raman Spectroscopy (SERS) technology, a detection method with the advantages of rich information, more sensitivity, higher-efficiency, no sample pretreatment and being available in situ, can be applied in detecting single molecule. And it is expected to achieve real-time and rapid detection of antibiotics in aquiculture water. Surface-enhanced Raman spectroscopy was applied to detection of the antibiotics(chloramphenicol, ciprofloxacin, enrofloxacin) which were