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plga纳米h替莫唑胺微球的制备及其缓释性能的研究.pdf

plga纳米h替莫唑胺微球的制备及其缓释性能的研究.pdf

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plga纳米h替莫唑胺微球的制备及其缓释性能的研究

waswerewaswaswithwaswaswithMTTmoreU87U8U87VIreleaseusedbothrateraterateanaThehavenHAnHAreleaseononTMZ·Thereleasekineticreleaseresultsremarkedrod—likereleasevitroofandandalsoandandofofofobvious.ofofoftocellcellsfitf.rom7twothedatadiscussed.cellconcentrationcultureddemonstratedcellthethethethetheevaluatedthattheeffectexhibitstimeeffectthethethethethatthesurfaceslowersolventlastinfluenceindicatedinhabitationinhibitorvisin 4.3.34.42.5.12.5.23.4.13.4.23.33.3.23.3.33.4.VTTI. 一一一一~~~~~~~~~~ Metallicll.2. .2. Derived.4. HAHAOd0ofofectionstructurestructure11.S. .6. .7. .8. 0..1 11.11. 94.13..1 MoleculeTMZ4.ofstructure.1 of.15. .17. 8H209.0CaCl2+6Na2HP04+8NH40H-*CaI2NaCI+8NH4CI+6H2011.1 .20. .21. waterbalanceofstate.22. 2.5.1.23. 2.5.2..24.. 77..25.. 7EE2.5.3.26. ..27.. AldrichAldrichmaterialusedusedTherawTab.3.1TheTab.3.2andthetheinin..29.. 3.3.23.3..30.. AbsorbanceaTab.3.3The4.272470.04.968TMZ一values400.06.250.700curve25.0200.02.024of0.1440.2900.576of50.0standardstandard100.012.51.036.31. PLGA3i--13.3.33.4.13.4..32.. PLGAEmulhTMZCH2C12一一一Schemeoffor一the3.4.2.33.I UVTestTab.3.4Tab.3.5Theresultofandof..34.. ofSEM.35. ..36.. UmnCOEaSCScheme一一一offorthe一..37..I EmulsionEmulsionSketchandofthefor.38. AldrichAldrichAldrichmaterialusedusedTab.4.1TherawTheandthetheinin..39.. B.VPro..40.. XRD40of4.3.33050..41.. FTIRnHAof63038~1084—11570~57411~11-61 AnHATab.4.3TheTEMTMZratio4.4.1ofofnHA4.4tothein.43.. ABBbbbbbbbTheaaTab.4.4Tab.4.5TheTheO4OO44O44OO4aaaaaTMZratioO998898899ofnHAof066000000060660000000622222of33535533535thellllllin1111111111inin..44.. BXRD4.4.24.4.3of..45.. BFTIRFTIRTMZof4.4.4of..46.. AAABb.1TheTheTab.4.7Tab.4.84.2246.40+6.1TMZTMZa.7of0.50.80.2430.3880.4870.48400.70.2970.424of0.1920.2170.3052.65250.592.09ofofcontent399.2693.237306.08content3.327314.602.368223.79thethelin11.21.4197.4615.9715.521.619.09in..47.. ..48.. ABTab.4.9TheTab.4.1TheTMZTMZ0ofofthetheinin..49.. ABTheTab.4.1TheTab.4.1amountamount2ofof11inin..50..

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