3,4-二苯基香豆素衍生物的合成及其促自然杀伤细胞活性研究有机化学.pdfVIP

DOI: 10.6023/cjoc201208022 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 3,4-二苯基香豆素衍生物的合成及其促自然杀伤细胞活性研究 陈 华a 周利凯a 李 帅a 姚玉超a 谷云景a 李春晓b 李 娜b 孟 明*,b 李小六*,a (a 河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 071002) (b 河北大学医学部 保定 071002) 摘要 以水杨酸为起始原料, 经 Fridel-Crafts 酰基化反应、微波促进的 Perkin 反应和两步亲核取代反应, 合成了具有氨 基烷氧侧链的 3,4-二苯基香豆素衍生物 1a～1e. 初步生物活性测试表明, 化合物 1a～1e 能显著促进自然杀伤细胞杀伤 活性, 具有较强的免疫调节活性. 关键词 香豆素; Perkin 反应; 自然杀伤细胞; 免疫调节活性 Synthesis of 3,4-Biphenyl Coumarin Derivatives and Their Promoting Effects on the Killing Activity of Natural Killing Cell Chen, Huaa Zhou, Likaia Li, Shuaia Yao, Yuchaoa Gu, Yunjinga Li, Chunxiaob Li, Nab Meng, Ming*,b Li, Xiaoliu*,a a ( Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002) (b Medical School , Hebei University, Baoding 071002) Abstract A series of novel 3,4-biphenyl coumarin derivatives containing an amino side chain 1a～1e were synthesized using salicylic acid as starting material via Fridel-Crafts acylation, then the microwave-assisted Perkin reaction and double S 2 sub- N stitution reactions. The preliminary biological evaluation showed that compounds 1a～1e had significant promoting effects on the killing activity of nat