5-(2-羟基苯基)-1,3,4-噻二唑-2-硫基乙酰腙化合物的合成及抑菌活性有机化学.pdfVIP

DOI: 10.6023/cjoc201206013 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 5-(2-羟基苯基)-1,3,4-噻二唑-2-硫基乙酰腙化合物的合成及抑菌活性 王应红 杨 录 刘志昌* (乐山师范学院化学学院 乐山 614000) 摘要 以2-巯基-5-(2-羟基苯基)-1,3,4-噻二唑为原料, 经硫醚化、肼解、腙化反应合成了 9 个 5-(2-羟基苯基)-1,3,4-噻二 唑-2-硫基乙酰腙化合物, 其结构由 1H NMR, 13C NMR, IR, MS 表征和元素分析, 并初步研究了目标化合物的抑菌活性. 结果表明它们大多数具有优良的抑菌活性, 芳香醛-5-(2-羟基苯基)-1,3,4- 噻二唑-2-硫基乙酰腙(4a ～4h) 比 2-丁烯 醛-5-(2-羟基苯基)-1,3,4-噻二唑-2-硫基乙酰腙(4i)有更好的抑菌活性. 关键词 2-巯基-5-邻羟基苯基-1,3,4-噻二唑; 酰腙; 合成; 抑菌活性 Synthesis and Antibacterial Activity of 5-(2-Hydroxyphenyl)-1,3,4- thiadiazol-2-yl-sulfanyl Acetyl Hydrazones Wang, Yinghong Yang, Lu Liu, Zhichang* (Department of Chemistry, Leshan Normal University, Leshan 614000) Abstract A series of 5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazones were synthesized with 2-mercapto-5-(2-hydroxyphenyl)-1,3,4-thiadiazole as starting material, followed by thioetherification, hydrazide reaction and hydrazone reaction. The structures of these compounds were characterized by 1H NMR, 13C NMR, IR, MS techniques and elemental analysis. The antimicrobial activities of these compounds were also originally studied. The results showed that most of these compounds have potent antibacterial activities. These compounds of aromatic aldehyde-5-(2-hydroxyphen-yl)-1,3,4- thiadiazol-2-yl-sulfanyl acetyl hydrazone (4a～4h) showed better antibacterial activities than 2-butenal-5-(2-hydroxyphenyl)- 1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazone (4i). Keywords 2-mercapto-5-(2-hydroxyphenyl)-1,3,4-thiadiazole; acyl hydrazones; synthesis; antibacterial activity