水中取代水杨醛和氰乙酸酯的反应研究有机化学.pdfVIP

2006 年第 26 卷 有 机 化 学 Vol. 26, 2006 第 10 期, 1379～1383 Chinese Journal of Organic Chemistry No. 10, 1379～1383 ·研究论文· 水中取代水杨醛和氰乙酸酯的反应研究 王香善*,a,b,c 曾兆森 a 李玉玲 a,c 史达清 a,c 屠树江 a,c 魏贤勇 b b 宗志敏 (a 徐州师范大学化学系 徐州 221116) (b 中国矿业大学化学工程学院 徐州 221008) (c 江苏省药用植物生物技术重点实验 徐州 221116) 摘要 以水杨醛和氰乙酸酯为原料, 以水为溶剂, 以三乙基苄基氯化铵为催化剂在不同的反应温度下合成了两个系列 的色烯衍生物, 该方法具有反应条件温和、立体选择性好、产率高等优点. 关键词 色烯; 水杨醛; 氰乙酸酯; 三乙基苄基氯化铵; 水; 合成 Study on the Reaction of Substituted Salicylaldehydes with Cyanoacetate in Water WANG, Xiang-Shan*,a,b,c ZENG, Zhao-Sena LI, Yu-Linga,c SHI, Da-Qinga,c TU, Shu-Jianga,c WEI, Xian-Yongb ZONG, Zhi-Minb a ( Department of Chemistry , Xuzhou Normal University , Xuzhou 221116 ) (b School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008 ) (c Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116 ) Abstract Two series of chromene derivatives were synthesized from the substituted salicylaldehyde with cyanoacetate in water at two reaction temperatures catalyzed by triethylbenzyl ammonium chloride (TE- BAC). Such method has the advantages of easier work-up, milder reaction conditions, better yields than other synthetic methods.