焦脱镁叶绿酸-a的苯腙和氨基酸席夫碱的合成有机化学.pdfVIP

DOI: 10.6023/cjoc201401009 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 焦脱镁叶绿酸-a 的苯腙和氨基酸席夫碱的合成 杨晓英a 谭广慧a,b 曲凤玉a,b 金英学*,a 王进军*,c (a 哈尔滨师范大学化学化工学院 哈尔滨 150025) (b 哈尔滨师范大学生命科学技术学院 哈尔滨 150025) (c 烟台大学化学化工学院 烟台 264005) 摘要 以焦脱镁叶绿酸-a 甲酯为原料, 通过 E-环羰基分别与苯肼和氨基酸反应合成了焦脱镁叶绿酸-a 甲酯苯腙和焦脱 镁叶绿酸-a 氨基酸席夫碱. 苯腙的最大吸收波长显著红移. 席夫碱最大吸收波长稍有蓝移, 而其水溶性明显增大. 所有 新化合物的结构经 1H NMR, MS 或元素分析所证实. 关键词 光动力治疗; 焦脱镁叶绿酸-a 甲酯(Mppa); 苯腙; 氨基酸; 席夫碱; 水溶性 Synthesis of Phenylhydrazone and Amino acid Schiff Base of Pyropheophorbide-a Yang, Xiaoyinga Tan, Guanghuia,b Qu, Fengyua,b Jin, Yingxue*,a Wang, Jinjun*,c (a College of Chemistry Chemical Engineering, Harbin Normal University, Harbin 150025) b ( College of Life Science and Biotechnology, Haerbin Normal University, Harbin 150025) (c College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005) Abstract Methyl pyropheophorbide-a was used as starting material for the synthesis of phenylhydrazone and amino acid 1 Schiff base by reactions of carbonyl group at 13 -position. The maximum absorption wavelength of phenylhydrazone caused a red shift. The water-solubility of Schiff base was incremented, and the maximum absorption wavelength shifted hypsochromi- cally. The structures of all these compounds were characterized by 1H NMR, MS and elemental analysis. Keywords photodynamic ther