环境友好型Michael加成的研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201312034 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 环境友好型Michael 加成的研究进展 李志峰a 侯海亮a 应安国*,b 许松林*,a (a 天津大学化工学院 天津 300072) (b 台州学院医药化工学院 台州 318000) 摘要 Michael 加成反应是有机合成领域一类非常重要的反应. 随着人们环保意识的增强和对绿色化学研究的深入, 环 境友好型 Michael 加成取得了诸多成功. 综述了近 5 年来离子液体、酶催化、负载固相催化、聚乙二醇(PEG)等参与的 Michael 加成反应的研究进展. 着重分析了反应体系的高效性、催化剂可能的催化反应机理以及催化剂的循环使用性, 并以此对环境友好型 Michael 加成的发展做出了展望. 关键词 Michael 加成; 环境友好; 催化; 绿色化学 Research Progress in the Environmentally-Friendly Michael Addition Li, Zhifenga Hou, Hailianga Ying, Anguo*,b Xu, Songlin*,a a ( School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072) b ( School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000) Abstract Michael addition is one kind of important reaction in the organic field. With the enhancement of environmental awareness and the depth of green chemistry research, environmentally-friendly Michael addition has made many successes. The research progress over the past 5 years in the Michael addition involving ionic liquids, enzyme catalysis, solid phase sup- ported catalysis and polyethylene glycol (PEG) is reviewed. This paper is consisted of six parts, focusing on the efficiency of the reaction system, the probable catalytic mechanism and the recycle of the catalyst. In the first part, a brief introduction is given. Then the Michael addition used the ionic liquid as c