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Histopathological Variants of Cutaneous Squamous Cell Carcinoma A Review.pdf
Hindawi Publishing Corporation
Journal of Skin Cancer
Volume 2011, Article ID 210813, 13 pages
doi:10.1155/2011/210813
Review Article
Histopathological Variants of Cutaneous Squamous Cell
Carcinoma: A Review
Valerie R. Yanofsky,1 Stephen E. Mercer,2 and Robert G. Phelps2
1Albert Einstein College of Medicine, Bronx, NY 10461, USA
2 Division of Dermatopathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, USA
Correspondence should be addressed to Stephen E. Mercer, mercerse@
Received 1 August 2010; Accepted 4 November 2010
Academic Editor: J. W. Patterson
Copyright © 2011 Valerie R. Yanofsky et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Nonmelanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population, with squamous cell car-
cinoma (SCC) accounting for the majority of NMSC-related metastases and death. While most SCC lesions are indolent tumors
with low malignant potential, a wide diversity of SCC subtypes exist, several of which are associated with markedly more aggressive
behaviors. Distinguishing these high-risk variants from their counterparts is possible through microscopic analysis, since each
subtype possesses unique histopathological features. Early identification of high-risk lesions can allow for more rapid therapeutic
intervention, reducing the likelihood of metastasis and death. The authors review specific histopathological features and associated
clinical outcomes of the primary subdivisions of SCC.
1. Introduction biological behaviors, with minimal competence for distant
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