使用极端样本构建一个基于熵对数量性状位点关联研究统计量.pdfVIP

◎ 生物数学学报2008，234()：605—611BioJmouartnhaemlatoifcs AnEntropy—BasedStatisticforGenomicAssociation StudyforQTLinExtremeSamplesofPopulation XIANG Yang ，。 LIYu—Mei·。 LIU Za1．Ming2 (1DepartmentofMathematics，HuaihuaUniversity HuaihuaHunan418008China) (2CollegeofMathematics，CentralSouthUniversity，ChangshaHunan410081China) (3SchoololPublicHealth，CentralSuothUniversity，ChangshaHunan410078China) Abstract： Anentropy—basedstatistichas beenproposedbyZhaoeta1．forgenomic associationstudyofrdisease-susceptibilitylocus．Weextendthistheorytoquantitative traitandobtainanentropy—basedstatisticforassociationanalysisofquantitative-trait locus(QTL)usingseriesoflinkedmarkerlocifromextremeindividualsinpopulations． Keywords：Entropy；Quantitative-traitlocus；Associationanalysis；Extreme sample CLCnumber： Q34S MRnumber： 62P10；92D10 Documentcode： A ArticleID： 1001——9626(2008)04-0605——07 0 Introduction A novelteststatisticofrcase-controlgeneticassociationstudyofcomplexdiseasesthat usesShannonentropyhas beenproposedbyZhaoeta1．1．Throughcomparingtheentropyin haplotypeofmarkers—anonlinearfunctionofhaplotypefrequencies，inaffected individualsand unaffected individuals，andthusamplifyingthedifferencesinalleleandhaplotyperfequencies， theentropy—basedstatisticobtainedgreaterpowerthanthatofacommonstatsiticalmethodofr associationstudiesthroughcomparingallele(orhaplotype)rfequenciesbetweenaffectedandun- affected individuals[2—3I ． whichisoften referredtoas thestandard test．ItiSwellknownthat geneticanalysisofquantitativetraitlo(-us(QTL)canbeconductedbydichotomizingthequanti· tativetrait-usingasuitableanalyticalapproachwiththesamelogicfordichotomousdiseasei41。In thisarticle，weextendZhao’Sthoerytoquantitativetrait，andobtainanentropy—basedstatistic ofrassociationanalysisofquantitative-traitlocus(QTL)usingseriesoflinkedmrak