原创力文档a novel sphingosine-1-phosphate receptor agonist krp-203 attenuates rat autoimmune myocarditis：一种新的1-磷酸鞘氨醇受体激动剂krp-203减轻大鼠自身免疫性心肌炎.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a novel sphingosine-1-phosphate receptor agonist krp-203 attenuates rat autoimmune myocarditis：一种新的1-磷酸鞘氨醇受体激动剂krp-203减轻大鼠自身免疫性心肌炎
Biochemical and Biophysical Research Communications 361 (2007) 621–628
/locate/ybbrc
A novel sphingosine-1-phosphate receptor agonist KRP-203
attenuates rat autoimmune myocarditis
Ryo Ogawa a, Masafumi Takahashi a,*, Sho-ichi Hirose a, Hajime Morimoto a,
Hirohiko Ise a, Takashi Murakami b, Tokutaro Yasue c, Kazuhiko Kuriyama c,
Minoru Hongo d, Eiji Kobayashi b, Uichi Ikeda a
a Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine,
3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
b Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
c Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan
d Department of Cardiovascular Medicine, Shinshu University School of Health Sciences, Matsumoto, Japan
Received 10 July 2007
Available online 23 July 2007
Abstract
Sphingosine-1-phosphate (S1P) is an active sphingolipid metabolite that exerts important biological effects. Recently, we demon-
strated that KRP-203 is a novel S1P receptor agonist that can alter lymphocyte homing and act as an immunomodulating agent. We
investigated the efficacy of KRP-203 in the treatment of rat experimental autoimmune myocarditis. KRP-203 significantly attenuated
the inflammation area, heart weight/body weight ratio, and left ventricular function. Immunohistochemical analysis and RT-PCR
reveal
您可能关注的文档
- 【临床医学培训课件】概论1 (1).ppt
- a novel algorithm for colour image steganography using a new intelligent technique based on three phases：一种新的基于三个相位的彩色图像隐写算法.pdf
- a novel algorithm of extended neural networks for image recognition：一种新的扩展神经网络图像识别算法.pdf
- a novel and provably secure biometrics-based three-factor remote authentication scheme for mobile client–server networks：一种新型的和可证明安全的生物识别技术为基础的三因素的远程身份认证方案的移动客户端–服务器网络.pdf
- a novel ant colony optimization based scheme for substitution box design：一种基于蚁群优化的置换盒设计方案.pdf
- a novel apoa-i truncation (apoa-imytilene) associated with decreased apoa-i production：一种新型apoa-1截断（apoa imytilene）减少apoa-i生产相关.pdf
- a novel approach based on dematel method and patent citation analysis for prioritizing a portfolio of investment projects：基于dematel方法和专利引文分析的优先投资项目组合的新方法.pdf
- a novel antibody targeting cd24 and hepatocellular carcinoma in vivo by near-infrared fluorescence imaging：一种新型抗体靶向cd24和肝细胞癌的实验研究利用近红外荧光成像.pdf
- a novel approach for fuzzy logic pv inverter controller optimization using lightning search algorithm：一种基于模糊逻辑的光伏逆变器控制器优化设计方法.pdf
- a novel approach for monitoring writing interferences during navigated transcranial magnetic stimulation mappings of writing related cortical areas：写作过程中监测干扰导航经颅磁刺激映象写作相关的皮层区域的一种新方法.pdf
- a novel solution to the klein–gordon equation in the presence of a strong rotating electric field：一种新型的克莱因-戈登方程在强旋转电场作用下的求解.pdf
- a novel subpopulation of peripheral blood mononuclear cells presents in major burn patients：主要烧伤患者外周血单个核细胞亚群的研究.pdf
- a novel ta：一种新的助教.agp.s.1b transcript in chinese common wheat (triticum aestivum l.).pdf
- a novel topology aggregation approach for shared protection in multi-domain networks：一种新的多域网络共享保护拓扑聚合方法.pdf
- a novel similarity-based hysteresis empirical model for piezoceramic actuators：一种新的基于相似性的压电陶瓷致动器磁滞模型.pdf
- a novel unscented predictive filter for relative position and attitude estimation of satellite formation：相对位置和姿态估计卫星形成一种无迹预测滤波器.pdf
- a novel third generation uric acid biosensor using uricase electro-activated with ferrocene on a nafion coated glassy carbon electrode：一种新型第三代尿酸生物传感器采用尿酸酶电在nafion修饰玻碳电极的二茂铁活性.pdf
- a novel virtual identity implementation for anonymous communication in cloud environments：云环境下匿名通信的一种新的虚拟身份实现.pdf
- a novel therapeutic strategy for mycoplasma infectious diseases：一种治疗支原体感染性疾病的新方法.pdf
- a novel vertical stepped doping poly-si tft (vsd-tft) for leakage current improvement：一个新的垂直阶梯掺杂多晶硅薄膜晶体管（vsd-tft）泄漏电流的改进.pdf
文档评论（0）