原创力文档a randomised, double-blind study comparing the addition of bicalutamide with or without dutasteride to gnrh analogue therapy in men with non-metastatic castrate-resistant prostate cancer：一项随机，双盲研究比较比卡鲁胺或添加不度他雄胺gnrh类似物治疗男性非转移性阉割性前列腺癌.pdfVIP
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a randomised, double-blind study comparing the addition of bicalutamide with or without dutasteride to gnrh analogue therapy in men with non-metastatic castrate-resistant prostate cancer：一项随机，双盲研究比较比卡鲁胺或添加不度他雄胺gnrh类似物治疗男性非转移性阉割性前列腺癌
European Journal of Cancer (2015) 51, 1555–1569
A v a i l a b l e a t w w w . s c i e n c e d i r e c t. c o m
ScienceDirect
journal homepag e:
A randomised, double-blind study comparing the addition
of bicalutamide with or without dutasteride to GnRH
analogue therapy in men with non-metastatic castrate-
resistant prostate cancer
a,⇑ b c d
Franklin M. Chu , Oliver Sartor , Leonard Gomella , Todd Rudo ,
Matthew C. Somerville e,1, Belinda Hereghty e,1, Michael J. Manyak e
a San Bernardino Urological Associates, 489 E. 21 Street, San Bernardino, CA 92404, USA
b Medicine and Urology Departments, Tulane School of Medicine, Box SL-42 1430 Tulane Ave, New Orleans, USA
c Department of Urology, Sidney Kimmel Cancer Center, Thomas Jefferson University, 111 South 11th Street, Philadelphia, PA 19107, USA
d GlaxoSmithKline, 1250 S Collegeville Rd, Collegeville, PA 19426, USA
e GlaxoSmithKline, 5 Moore Drive, PO Box 13398, Research Triangle Park, North Carolina, NC 27709, USA
Received 27 January 2015; received in revised form 1 April 2015; accepted 28 April 2015
Available online 2 June 2015
KEYWORDS Abstract Background: Bicalutamide blocks androgen action and is frequently used in men
Castration-resistant pros- with non-metastatic, castration-resistant prostate cancer (CRPC). By reducing intracellular
tate cancer (CRPC) dihydrotestosterone, dutasteride (dual 5-alpha reductase inhibitor) could increase the effec-
Dutasteride tiveness of bicalutamide in this setting. The objective of the study is therefore to prospectively
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