原创力文档a randomized, double-blind, multicenter comparison of gatifloxacin versus ciprofloxacin in the treatment of complicated urinary tract infection and pyelonephritis：一项随机，双盲，加替沙星与复杂性尿路感染、肾盂肾炎的治疗的多中心比较环丙沙星.pdfVIP
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a randomized, double-blind, multicenter comparison of gatifloxacin versus ciprofloxacin in the treatment of complicated urinary tract infection and pyelonephritis：一项随机，双盲，加替沙星与复杂性尿路感染、肾盂肾炎的治疗的多中心比较环丙沙星
CLINICAL THERAPEUTICS®/VOL.24, NO. 2, 2002
A Randomized, Double-Blind, Multicenter Comparison
of Gatifloxacin Versus Ciprofloxacin in the Treatment
of Complicated Urinary Tract Infection and Pyelonephritis
Clair E. Cox, MD, 1 Thomas C. Marbury, AID, z Walter G. Pittman, MD, 3
Gary L. Brown, AID, 4 Stephen M. Auerbach, MD, s Barry C. Fox, MD, 6
and Joanna Y. Yang, PhD 7
1Universityof Tennessee,Memphis, Tennessee,2Orlando ClinicalResearch Center,
Orlando, Florida, 3LloydNolan UrologyCenter,Fairfield,Alabama, 4pharmaTex
Research, Amarillo, Texas,5CaliforniaProfessionalResearch, Newport Coast,
California, 6Dean Clinic,Madison, Wisconsin,and 7Bristol-MyersSquibb Company,
Wallingford, Connecticut
ABSTRACT
Background: Gatifloxacin is a fluoroquinolone antibiotic with a broad spectrum of in
vitro and in vivo activity against the gram-negative and gram-positive pathogens fre-
quently implicated in urinary tract infections (UTIs).
Objective: This study compared the clinical and bacteriologic efficacy and tolerability of
gatifloxacin versus ciprofloxacin in adult patients with complicated UTIs or pyelonephritis.
Methods: In this double-blind, multicenter, randomized, comparative study, patients
were treated with either gatifloxacin 400 mg once daily or ciprofloxacin 500 mg twice
daily for 7 to 10 days. Bacteriologic eradication (by quantitative urine culture) and clin-
ical efficacy rates were assessed at a test-of-cure visit (5 to 9 days and 4 to 11 days post-
treatment, respectively) and at an extended follow-up visit (29-42 days and 25-50 days
posttreatment, respectively).
Results: A total of 372 adults were randomized to treatment, 189 to gatifloxacin and
183 to ciprofloxacin. The most commo
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