腰椎终板modc退变与髓核内炎症因子的相关性研究.pdfVIP

o 中 文 摘 要 Modie退变即在MRI影像学检查中，腰椎间盘退变性疾病中椎间盘终板信号的改 变oMRI信号的改变反映了腰椎终板的病变，与椎问盘退变密切相关。椎间盘重复的 创伤可刺激髓核内部炎性物质IL—18，VEGF，n晒一a的产生，炎症物质通过椎体终板 的扩散可以引起局部的炎症反应，而导致疼痛。目的 旨在探讨腰椎终板退变的Modic 而为下腰痛病变的明确诊断提供依据。方法：50个病人男35例，女15例，取其髓核组织 作为研究样本。所有病人都有下腰痛的症状。根据病人术前磁共振影像上有无MC分 05)，Modic退变组软骨含量明显为高而髓核含量明显为低，而二组间纤维环成分无差 别。终板退变与腰椎间盘退变密切相关。髓核内炎性因子TNF—a和IL一1p在无MC 关系。而由于病例的病程较长使行其表达量过低，从而使VEGF在两组中无显著差异。 关键词腰椎终板髓核内炎症因子下腰痛 o TheCorrelationof Lumbar Endplate Degenerative Modicand FactorswithintheNucleus Inflammatory Abstract Vertebra diseasehas formand theinterverte— degenerativemany appearance，especially callmakethevertebraterminal bral intervertebral changed． ligament．The ligament plate Andthe oftheintervertebral WaSnamedtheMedic．Thewound message ch,ged ligament callmake oftheintervertebralleadtothe factors ligament IL—lp，VEGF，TNF—a．These the in The betweentheMedicandtheinflam- relationship inflammatorypartly．Objective ofthelower factorsofthevertebralWaSstudied．Thedoctanenmtion matory pulp diagnosis was causesof62vertebral back 50 35，female15)were pain provided．Method pulps(male and Medic st