关节软骨的2型胶原.pdf

Available online /content/4/1/030 Review Collagen of articular cartilage David Eyre Orthopædic Research Laboratories, Department of Orthopædics and Sports Medicine, University of Washington, Seattle, Washington, USA Correspondence: David R Eyre, PhD, Department of Orthopædics and Sports Medicine, University of Washington, Box 356500, Seattle, WA 98195-6500, USA. Tel: +1 206 5434700; fax: +1 206 685 4700; e-mail: deyre@ Received: 5 June 2001 Arthritis Res 2002, 4:30-35 Accepted: 4 September 2001 © 2002 BioMed Central Ltd Published: 5 October 2001 (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens IX and XI in this heteropolymer are not yet fully defined but, evidently, they are critically important since mutations in COLIX and COLXI genes result in chondrodysplasia phenotypes that feature precocious osteoarthritis. Collagens XII and XIV are thought also to be bound to fibril surfaces but not covalently attached. Collagen VI polymerizes into its own type of filamentous network that has multiple adhesion domains for cells and other matrix components. Collagen X is normally restricted to the thin layer of calcified cartilage that interfaces a