英-gspe保护关节炎.pdf

Immunology Letters 124 (2009) 102–110 Contents lists available at ScienceDirect Immunology Letters j o u rn al h omepage: w w w. elsev /locate/ Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis Mi-La Cho 1, Yu-Jung Heo 1, Mi-Kyung Park, Hye-Jwa Oh, Jin-Sil Park, Yun-Ju Woo, Ji-Hyeon Ju, Sung-Hwan Park, Ho-Youn Kim, Jun-Ki Min ∗ The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea a r t i c l e i n f o a b s t r a c t Article history: To examine whether grape seed proanthocyanidin extract (GSPE) which is known to act as an antioxi- Received 23 March 2009 dant has therapeutic effect on collagen-induced arthritis (CIA) in mice, an animal model of rheumatoid Received in revised form 29 April 2009 arthritis. Mice were treated with an intraperitoneal injection of GSPE (10, 50, or 100 mg/kg) or saline. Accepted 3 May 2009 Clinical, histological, and biochemical parameters were assessed. The effects of GSPE on osteoclasto- Available online 14 May 2009 genesis were determined by tartrate-resistant acid phosphatase (TRAP) staining of the inflamed joints and bone-marrow cells cultured with the receptor activator of nuclear factor B ligand (RANKL) and Keywords: macrophage colony-stimulating factor (M-CSF). Intracellular levels